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The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity

Cycling Details Community protocols have shifted toward starting low and building up rather than front-loading a full dose

Consider risk factors for medication adverse events (e.g

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Dunne FP, Chowdhury TA, Hartland A, et al

As of July 2025, IQVIA estimated more than 2 million UK adults were paying out of pocket for anti-obesity medications, against approximately 220,000 receiving them through the NHS: a ratio of around nine to one